abstract：:The renin-angiotensin system (RAS) is a key regulator of vascular resistance, sodium and water homeostasis and the response to tissue injury. Historically, angiotensin II (Ang II) was thought to be the primary effector peptide of this system. Ang II is produced predominantly by the effect of angiotensin converting enz...

journal_title：Journal of gastroenterology and hepatology

authors： Lubel JS,Herath CB,Burrell LM,Angus PW

更新日期：2008-09-01 00:00:00

abstract：BACKGROUND AND AIM:Increased production of reactive oxygen species, which cause oxidative DNA damage, is considered to be related to hepatocarcinogenesis. 8-Hydroxy-2'-deoxy-guanosine (8-OHdG) is a useful marker of DNA damage induced by oxidative stress. The aim of this study was to determine whether expression of 8-OH...

journal_title：Journal of gastroenterology and hepatology

authors： Chuma M,Hige S,Nakanishi M,Ogawa K,Natsuizaka M,Yamamoto Y,Asaka M

更新日期：2008-09-01 00:00:00

abstract：BACKGROUND AND AIMS:We have recently reported quantitative and qualitative differences of the bone marrow (BM) hematopoietic progenitor cells in autoimmune hepatitis type-1 (AIH-1) and primary biliary cirrhosis (PBC). In order to better investigate the possible involvement of BM in these diseases, we studied the morpho...

journal_title：Journal of gastroenterology and hepatology

authors： Tsikrikoni A,Rigopoulou EI,Zachou K,Liaskos C,Kyriakou D,Dalekos GN

更新日期：2008-08-01 00:00:00

abstract：BACKGROUND AND AIM:Bacterial metabolites produced in the bowel are potentially related to the genesis of colorectal cancer. Butyrate is protective against cancer, whereas hydrogen sulfide and oxygen free radicals can be toxic to the epithelium. The present study was designed to quantitate Eubacterium rectale, Faecaliba...

journal_title：Journal of gastroenterology and hepatology

authors： Balamurugan R,Rajendiran E,George S,Samuel GV,Ramakrishna BS

更新日期：2008-08-01 00:00:00

abstract：:The main goals of chronic hepatitis B treatment should be the long-term suppression of viral replication to minimize disease progression and the risk for the development of hepatocellular carcinoma. Treatment end-points, depending on surrogate markers alone, in particular hepatitis B e-antigen seroconversion, may not ...

journal_title：Journal of gastroenterology and hepatology

authors： Fung J,Lai CL,Yuen MF

更新日期：2008-08-01 00:00:00

abstract：BACKGROUND AND AIM:To study the histological changes caused by transfection of the hepatocyte growth factor (HGF) gene using electroporation (EP) in a non-alcoholic steatohepatitis (NASH) cirrhotic liver model. METHODS:NASH cirrhotic livers were prepared by administering a choline-deficient diet to 5-week-old male Wis...

journal_title：Journal of gastroenterology and hepatology

authors： Kiyama S,Yamada T,Iwata H,Sekino T,Matsuo H,Yoshida N,Miyahara T,Umeda Y,Matsuno Y,Kimura M,Matsumoto K,Nakamura T,Takemura H

更新日期：2008-08-01 00:00:00

abstract：BACKGROUND:Cystinosis is a metabolic disease characterized by accumulation of cystine in different organs and tissues, leading to potentially life-threatening organ dysfunction. Infantile cystinosis typically leads to end-stage renal disease, necessitating renal replacement therapy. Liver disease in cystinosis is rare ...

journal_title：Journal of gastroenterology and hepatology

authors： Cornelis T,Claes K,Gillard P,Nijs E,Roskams T,Lombaerts R,Nevens F,Cassiman D

更新日期：2008-08-01 00:00:00

abstract：BACKGROUND AND AIM:It has been reported that immunological factors, such as the T-helper cell (Th)1/Th2 ratio, play a part in the mechanisms for the antihepatitis C virus (HCV) effect of the interferon (IFN) alpha-2b plus ribavirin combination therapy. By using flow cytometry, we examined this ratio during a 24-week co...

journal_title：Journal of gastroenterology and hepatology

authors： Fujimoto T,Tomimatsu M,Iga D,Endo H,Otsuka K

更新日期：2008-08-01 00:00:00

abstract：BACKGROUND AND AIM:Hepatitis C virus (HCV) and environmental hepatotoxins may have an indirect influence on health by altering the synthesis and function of hormones, particularly reproductive hormones. We aimed to evaluate liver diseases and sex steroid hormones in Egypt, which has the highest prevalence of HCV worldw...

journal_title：Journal of gastroenterology and hepatology

authors： Aguilar CE,Soliman AS,McConnell DS,Zekri AR,Banerjee M,Omar A,Sharawy M,Omar S,Raouf A,Sowers MR

更新日期：2008-07-01 00:00:00

abstract：BACKGROUND AND AIM:Hepatocellular carcinoma (HCC) is characteristically a hypervascular tumor and its progression is known to be closely related to angiogenesis. In this study, we investigated angiopoietin-2 (Ang-2) and vascular endothelial growth factor (VEGF) levels in the hepatic vein draining from HCC, as well as i...

journal_title：Journal of gastroenterology and hepatology

authors： Kuboki S,Shimizu H,Mitsuhashi N,Kusashio K,Kimura F,Yoshidome H,Ohtsuka M,Kato A,Yoshitomi H,Miyazaki M

更新日期：2008-07-01 00:00:00

abstract：BACKGROUND AND AIMS:Low-grade erosive esophagitis (i.e. Los Angeles grade A) is the most predominant type of esophagitis in Japan. It is unclear whether all the mucosal breaks detected by conventional endoscopy are indicative of esophageal mucosal erosion. Hospital-based, cross-sectional, cross-over, observational stud...

journal_title：Journal of gastroenterology and hepatology

authors： Amano Y,Yamashita H,Koshino K,Ohshima T,Miwa H,Iwakiri R,Fujimoto K,Manabe N,Haruma K,Kinoshita Y

更新日期：2008-07-01 00:00:00

abstract：BACKGROUND AND AIM:We previously reported that hypothermic machine perfusion (HMP) for liver preservation is feasible, but hepatic microcirculatory dysfunction and significant liver damage remain major obstacles in its application when the preservation is extended to 24 h. The underlying injury mechanism is not well un...

journal_title：Journal of gastroenterology and hepatology

authors： Xu H,Lee CY,Clemens MG,Zhang JX

更新日期：2008-07-01 00:00:00

abstract：BACKGROUND AND AIM:The present study was aimed to evaluate the hepatic zonation of multidrug resistance-associated protein 2 (mrp2), an important drug transporter, and its potential changes during the induction of its expression by known inducer, dexamethasone (DEX). METHODS:The hepatic expression of mrp2 was studied ...

journal_title：Journal of gastroenterology and hepatology

authors： Micuda S,Fuksa L,Brcakova E,Osterreicher J,Cermanova J,Cibicek N,Mokry J,Staud F,Martinkova J

更新日期：2008-07-01 00:00:00

abstract：BACKGROUND AND AIM:Based on our previous studies that Artemisia asiatica extracts exert either antioxidative or cytoprotective actions against non-steroidal anti-inflammatory drugs or Helicobacter pylori-induced gastric mucosal injury, or imposes qualified ulcer healing in an acetic acid-induced gastric ulcer model, we...

journal_title：Journal of gastroenterology and hepatology

authors： Park SW,Oh TY,Kim YS,Sim H,Park SJ,Jang EJ,Park JS,Baik HW,Hahm KB

更新日期：2008-06-01 00:00:00

abstract：BACKGROUND AND AIM:We assessed whether the two regimens of pegylated alpha-interferon-2b (PEG-IFN-alpha2b) plus ribavirin and pegylated alpha-interferon-2a (PEG-IFN-alpha2a) plus ribavirin showed differences in terms of sustained virological response, withdrawal due to side-effects and dose adjustment requirements in t...

journal_title：Journal of gastroenterology and hepatology

authors： Escudero A,Rodríguez F,Serra MA,Del Olmo JA,Montes F,Rodrigo JM

更新日期：2008-06-01 00:00:00

abstract：BACKGROUND AND AIM:Second-generation argon plasma coagulation (APC; APC 2/VIO APC) with its modes 'forced', 'pulsed', and 'precise' is a further development of the ICC/APC 300 system (first-generation APC). Until now, only limited data has existed on the use of APC 2. METHODS:Fundamental data on the characteristics of...

journal_title：Journal of gastroenterology and hepatology

authors： Manner H,Enderle MD,Pech O,May A,Plum N,Riemann JF,Ell C,Eickhoff A

更新日期：2008-06-01 00:00:00

abstract：BACKGROUND AND AIM:Endoscopic papillary balloon dilation (EPBD) has been advocated as an alternative therapy to endoscopic sphincterotomy for bile duct stones. However, studies have shown that EPBD may increase the risk for pancreatitis. Pancreatitis after EPBD is believed to be related to papillary damage after balloo...

journal_title：Journal of gastroenterology and hepatology

authors： Tsujino T,Kawabe T,Isayama H,Sasaki T,Kogure H,Togawa O,Arizumi T,Ito Y,Matsubara S,Yamamoto N,Nakai Y,Sasahira N,Hirano K,Toda N,Komatsu Y,Tada M,Yoshida H,Omata M

更新日期：2008-06-01 00:00:00

abstract：BACKGROUND AND AIM:Cholangiocarcinoma (CCA) is a mucin-producing cancer that has poor prognosis. Mucin 6 (MUC6) is a mucin that is normally co-expressed with the trefoil factor family-2 (TFF2) trefoil peptide. Both MUC6 and TFF2 have been reported to be involved in the progression of many types of cancers. The aim of t...

journal_title：Journal of gastroenterology and hepatology

authors： Thuwajit P,Chawengrattanachot W,Thuwajit C,Sripa B,Paupairoj A,Chau-In S

更新日期：2008-05-01 00:00:00

abstract：BACKGROUND AND AIMS:A prospective, non-randomized cohort study on long-term lamivudine treatment, comparing efficacy, drug resistance, and prognosis for various stages of chronic hepatitis B virus (HBV)-related liver disease was performed to elucidate the significance and indication of lamivudine for individual patient...

journal_title：Journal of gastroenterology and hepatology

authors： Nishida T,Kobashi H,Fujioka S,Fujio K,Takaguchi K,Ikeda H,Kawaguchi M,Ando M,Araki Y,Higashi T,Shoji B,Takaki A,Iwasaki Y,Sakaguchi K,Shiratori Y,Yamamoto K

更新日期：2008-05-01 00:00:00

abstract：BACKGROUND AND AIM:The ability to detect early squamous neoplasia of the esophagus can be enhanced considerably by iodine staining during endoscopic examination; however, there has been no study on distinguishing high-grade intra-epithelial squamous neoplasia from low-grade dysplasia by endoscopic examination. We assum...

journal_title：Journal of gastroenterology and hepatology

authors： Shimizu Y,Omori T,Yokoyama A,Yoshida T,Hirota J,Ono Y,Yamamoto J,Kato M,Asaka M

更新日期：2008-04-01 00:00:00

abstract：BACKGROUND AND AIMS:Histological examination of specimens obtained by forceps biopsy sampling of gastric lesions is of limited accuracy, and their management on this basis is therefore controversial. Endoscopic mucosal resection (EMR) was initially developed in Japan for the resection of early gastric cancer (EGC). The...

journal_title：Journal of gastroenterology and hepatology

authors： Szalóki T,Tóth V,Németh I,Tiszlavicz L,Lonovics J,Czakó L

更新日期：2008-04-01 00:00:00

abstract：BACKGROUND AND AIM:Symptoms and complications of primary biliary cirrhosis (PBC) have been shown to impair patients' health-related quality of life (HRQOL) in the West. We aimed to measure the HRQOL and to determine the factors associated with worse HRQOL among the Chinese PBC patients in Hong Kong. METHODS:Chinese pa...

journal_title：Journal of gastroenterology and hepatology

authors： Wong GL,Law FM,Wong VW,Hui AY,Chan FK,Sung JJ,Chan HL

更新日期：2008-04-01 00:00:00

abstract：BACKGROUND AND AIM:As an important cytokine that modulate the cell cycle, the involvement of transforming growth factor beta-1 (TGF-beta1) in carcinogenesis has been extensively studied for many years. Literatures have demonstrated that TGF-beta1 gene polymorphisms may alter the risk of various cancers, such as lung, p...

journal_title：Journal of gastroenterology and hepatology

authors： Li T,Cao BW,Dai Y,Cui H,Yang HL,Xu CQ

更新日期：2008-04-01 00:00:00

abstract：BACKGROUND AND AIM:Gastric cancer is a major health burden in the Asia-Pacific region but consensus on prevention strategies has been lacking. We aimed to critically evaluate strategies for preventing gastric cancer. METHODS:A multidisciplinary group developed consensus statements using a Delphi approach. Relevant dat...

journal_title：Journal of gastroenterology and hepatology

authors： Fock KM,Talley N,Moayyedi P,Hunt R,Azuma T,Sugano K,Xiao SD,Lam SK,Goh KL,Chiba T,Uemura N,Kim JG,Kim N,Ang TL,Mahachai V,Mitchell H,Rani AA,Liou JM,Vilaichone RK,Sollano J,Asia-Pacific Gastric Cancer Consensus Co

更新日期：2008-03-01 00:00:00

abstract：:Alcoholic liver diseases (ALD) are frequently associated with iron overload. Until recently, the effects of ethanol in hepatic iron uptake and intestinal iron absorption have not been clarified in detail. Two possible mechanisms for iron overload are the uptake of iron into hepatocytes in a specific manner through the...

journal_title：Journal of gastroenterology and hepatology

authors： Kohgo Y,Ohtake T,Ikuta K,Suzuki Y,Torimoto Y,Kato J

更新日期：2008-03-01 00:00:00

abstract：:Alcohol induces Ca(2+)-dependent intracellular trypsinogen activation in the apical granular area via non-oxidative metabolites, such as fatty acid ethyl esters and fatty acids. Intracellular trypsinogen activation is a crucial initiating event in the development of acute pancreatitis, but the specific organelle in wh...

journal_title：Journal of gastroenterology and hepatology

authors： Petersen OH

更新日期：2008-03-01 00:00:00

abstract：BACKGROUND AND AIM:Mucosal injury caused by gastroesophageal reflux may result in changes in esophageal mucosal blood flow. Little is known about esophageal mucosal blood flow in patients with gastroesophageal reflux disease (GERD). Here we examined esophageal mucosal blood flow and the effects of treatment in patients...

journal_title：Journal of gastroenterology and hepatology

authors： Mine S,Iida T,Tabata T,Okada Y,Tanaka Y

更新日期：2008-02-01 00:00:00

abstract：BACKGROUND AND AIM:Non-alcoholic fatty liver disease is the result of an imbalance in hepatic lipid partitioning that favors fatty acid synthesis and storage over fatty acid oxidation and triglyceride secretion. The progressive, inflammatory disorder of steatohepatitis can be prevented or reversed by correcting this li...

journal_title：Journal of gastroenterology and hepatology

authors： Larter CZ,Yeh MM,Cheng J,Williams J,Brown S,dela Pena A,Bell-Anderson KS,Farrell GC

更新日期：2008-02-01 00:00:00

abstract：BACKGROUND:Self-expanding metal bile duct stents provide good palliation for inoperable malignant disease. However, problems may arise if metal stents are inserted before definitive histological diagnosis. The aim of this study was to evaluate the outcome of such patients. METHODS:A retrospective case note review was ...

journal_title：Journal of gastroenterology and hepatology

authors： Ayaru L,Kurzawinski TR,Shankar A,Webster GJ,Hatfield AR,Pereira SP

更新日期：2008-02-01 00:00:00

abstract：BACKGROUND AND AIM:Postoperative abdominal adhesion formation is a troublesome clinical problem and a common cause of intestinal obstruction, chronic pain and infertility. The aim of this study was to evaluate the effect of small bowel obstruction (SBO) on functional outcome and quality of life (QOL) in patients who ex...

journal_title：Journal of gastroenterology and hepatology

authors： Erkek AB,Remzi FH,Hammel JP,Akyuz M,Fazio VW

更新日期：2008-01-01 00:00:00

abstract：:Pancreatic adenocarcinoma is one of the leading causes of cancer death in the West, with a poor overall 5-year survival rate of only 4%. Late clinical presentation with an advanced disease results in a low rate of surgical intervention. Tumor serum marker CA 19-9 is sensitive, although not specific for the diagnosis o...

journal_title：Journal of gastroenterology and hepatology

authors： Sahani DV,Shah ZK,Catalano OA,Boland GW,Brugge WR

更新日期：2008-01-01 00:00:00

abstract：BACKGROUND:The efficiency of Helicobacter pylori eradication varies geographically, as do many parameters that might affect therapeutic efficiency. The aims of this study were to investigate the relationship between different genotypes of H. pylori and bacterium-related histopathological lesions in patients with duoden...

journal_title：Journal of gastroenterology and hepatology

authors： Zhao JJ,Wang JB,Yang L,Li Y

更新日期：2007-12-01 00:00:00

abstract：BACKGROUND:Arterial vasodilatation, which is a major factor in the pathogenesis of the hyperkinetic circulatory state and portal hypertension in cirrhosis, is due to arterial nitric oxide (NO) overproduction secondary to endothelial NO synthase (eNOS) and inducible NOS (iNOS) upregulation. However, in cirrhosis, the re...

journal_title：Journal of gastroenterology and hepatology

authors： Malyshev E,Tazi KA,Moreau R,Lebrec D

更新日期：2007-12-01 00:00:00

abstract：BACKGROUND:Treatment of post-transplantation recurrence of hepatitis B virus (HBV) infection despite prophylaxis with hepatitis B immunoglobulin (HBIG) and lamivudine combination therapy is not easy. Because HBV reinfection has a severe course and could result in graft failure in liver transplant recipients, prompt med...

journal_title：Journal of gastroenterology and hepatology

authors： Akyildiz M,Karasu Z,Zeytunlu M,Aydin U,Ozacar T,Kilic M

更新日期：2007-12-01 00:00:00

abstract：AIMS:The regulation of ornithine decarboxylase (ODC) gene expression and enzyme activity by corticosterone during rat liver regeneration induced by partial hepatectomy (PH) was evaluated. METHODS:Bilateral adrenalectomies were performed on ether-anesthetized rats 3 days before PH. Corticosterone in sesame oil was inje...

journal_title：Journal of gastroenterology and hepatology

authors： Ning Q,Li C,Wei K,He J,Xu C,Shao Q

更新日期：2007-11-01 00:00:00

abstract：BACKGROUND AND AIM:The activation of Rho proteins has been shown to lead to loss of polarity in cancer cells, as well as reorganization of the cytoskeleton and facilitation of cell motility, possibly resulting in their malignant potential. The clinicopathological significance of RhoA, however, is not yet well known in ...

journal_title：Journal of gastroenterology and hepatology

authors： Wang D,Dou K,Xiang H,Song Z,Zhao Q,Chen Y,Li Y

更新日期：2007-11-01 00:00:00

abstract：BACKGROUND AND AIM:Alpha-lipoic acid (ALA) has been shown to combat oxidative stress by quenching a variety of reactive oxygen species. It is involved in the regeneration of exogenous and endogenous antioxidants, chelation of metal ions, and repair of oxidized proteins. This study aimed to evaluate the potential benefi...

journal_title：Journal of gastroenterology and hepatology

authors： Kolgazi M,Jahovic N,Yüksel M,Ercan F,Alican I

更新日期：2007-11-01 00:00:00

abstract：BACKGROUND AND AIMS:Few data were available on the optimal diagnostic strategy for Chinese patients with hematochezia. We aimed to evaluate the impact of age and distal colonic findings on the yield of diagnostic strategies in young Chinese patients with hematochezia. METHODS:Consecutive outpatients aged less than 50 ...

journal_title：Journal of gastroenterology and hepatology

authors： Liou JM,Lin JT,Wang HP,Huang SP,Lin JW,Wu MS

更新日期：2007-11-01 00:00:00

abstract：BACKGROUND AND AIMS:Aberrant right subclavian artery (ARSA) is the most common congenital anomaly of the aortic arch occurring in 0.4-2.0% of the general population. Instead of arising from the brachiocephalic artery, the ARSA arises as the last branch from the aortic arch. The aim of this study was to determine the pr...

journal_title：Journal of gastroenterology and hepatology

authors： Yusuf TE,Levy MJ,Wiersema MJ,Clain JE,Harewood GC,Rajan E,Topazian MD,Wang KK

更新日期：2007-11-01 00:00:00

abstract：BACKGROUND:Toll-like receptors (TLRs) are involved in innate immunity. Certain viruses interact with TLRs and mediate antiviral effects as well as immune responses. The aim of this study was to investigate the effect of TLRs on pathogenesis in hepatitis C virus (HCV)-infected patients. METHODS:Peripheral blood mononuc...

journal_title：Journal of gastroenterology and hepatology

authors： Sato K,Ishikawa T,Okumura A,Yamauchi T,Sato S,Ayada M,Matsumoto E,Hotta N,Oohashi T,Fukuzawa Y,Kakumu S

更新日期：2007-10-01 00:00:00